​Microdosing After a Macrodose

Benefits of microdosing after macrodosing and safely navigating your psychedelic journey

A macrodose refers to the ingestion of a full/high dose of psychedelic substance, typically resulting in effects on perception, consciousness and cognition. The exploration of macrodosing and its benefits dates back to ancient civilizations. Numerous archaeological findings suggest the early utilization of entheogens in Mesoamerica's history. Examples include Olmec burial sites containing remains of the Bufo toad (Bufo marinus), effigies of mushrooms in Maya artifacts, and references in Spanish writings, all indicating significant engagement with psychoactive substances in Aztec culture.

Many other cultures incorporated psychedelic substances into religious rituals, healing practices and spiritual ceremonies. The formal study and understanding of the benefits of macrodosing began to emerge during the mid-20th century, particularly with the rise of psychedelic research in the 50s and 60s. María Sabina, a Mazatec curandera from Mexico, holds a significant place in the history of psychedelic mushrooms. Revered within her community for her spiritual wisdom and healing abilities, she became renowned beyond her native lands. María Sabina's profound knowledge of psilocybin-containing mushrooms led to her being referred to as the "bringer of psychedelic mushrooms to the gringos."

After experiencing the positive effects of macrodosing psychedelics, many individuals seek to extend and integrate those benefits into their daily lives. Microdosing, the practice of taking sub-perceptual doses of psychedelics, has gained popularity as a means of achieving this goal.

Fadiman's Approach to Microdosing:

The Fadiman Protocol, highly esteemed within the community, was developed by Dr. James Fadiman. Crafted with designated "off" days, this protocol offers a clear window to assess the effects of microdosing. Particularly beneficial for first-time microdosers, it allows for comparison between days with and without psilocybin. Duration of microdosing cycles typically ranges from 4 to 8 weeks, with potential for resetting tolerance through a 2 to 4-week break.

Microdosing Protocol:

• Day 1: Initial microdose
• Day 2: Transition day (no dosing, residual effects may linger)
• Day 3: Normal day (no dosing)
• Day 4: Second microdose

For instance, if the first dose is taken on Monday, abstain on Tuesday and Wednesday. The second dose is then administered on Thursday, followed by a rest period on Friday and Saturday. The third dose occurs on Sunday, repeating the cycle thereafter.

Stamets' Perspective on Microdosing:

The Stamets Stack, coined by Paul Stamets, integrates various supplements to form a nootropic stack. Stamets, a dedicated mycologist, delves into the medicinal properties of mushrooms. This protocol, inclusive of Lion's Mane, involves the stacking of multiple supplements.

Ingredients:

• 100mg (0.1g) of mushrooms
• 5–20 grams of whole or powdered Lion’s Mane OR 50–200mg of Lion’s Mane extract
• 75–200 mg of Niacin (Vitamin B3)

Microdosing Protocol:

• Days 1–4: Microdosing days
• Days 5–7: Transition days
• Days 8–11: Microdosing days
• Days 12–14: Transition days

Lion’s Mane, akin to psilocybin, promotes neurogenesis and nerve growth. According to Stamets, niacin facilitates the movement of Lion’s Mane and psilocybin compounds throughout the brain and blood barrier, thereby enhancing neural repair.

Benefits of Microdosing After a Macrodose

Integration and Reflection

Microdosing provides an opportunity for continued introspection and integration of insights gained from the macrodose experience into daily life.

Sustained Mood Enhancement

Following a macrodose, individuals may experience temporary mood upliftment. Microdosing can help sustain these positive mood effects over an extended period.

Enhanced Creativity and Cognitive Function

Both Fadiman's and Stamets' protocols suggest that microdosing may enhance creativity, problem-solving abilities, and cognitive flexibility, qualities that can be valuable in personal and professional endeavors.

Improved Emotional Resilience

Microdosing has been reported to promote emotional resilience and well-being, which can be particularly beneficial in managing stress and navigating life's challenges.

Imagine that Sarah recently underwent a macrodose experience with psilocybin mushrooms. During her journey, she experienced profound insights about the interconnectedness of all life and a deep sense of compassion for others. However, as the intensity of the experience waned, Sarah found herself struggling to fully integrate these insights into her daily life.

To support her integration process, Sarah decides to incorporate microdosing into her routine. Following Dr. James Fadiman's protocol, she begins taking small doses of psilocybin every few days. With each microdose, Sarah notices subtle shifts in her perception and mood, which serve as gentle reminders of the insights she gained during her macrodose experience.

During her microdosing sessions, Sarah engages in mindfulness practices such as meditation and journaling. These practices allow her to deepen her introspection and reflect on the lessons learned from her macrodose journey. She also takes time to connect with nature, recognizing the interconnectedness she experienced while under the influence of the macrodose.

Over time, Sarah finds that the integration process becomes more seamless as she continues to microdose. The insights gained from her macrodose experience begin to permeate her daily thoughts, behaviors, and interactions with others. She feels more grounded, compassionate, and aligned with her values, thanks to the ongoing support of microdosing.

Finding Your Balance

While both Fadiman's and Stamets' protocols offer potential benefits, it's crucial to find the dosing schedule that works best for you. Some individuals may thrive on Fadiman's every other day approach, finding it conducive to maintaining a steady level of creativity and mood enhancement. Others may prefer Stamets' five-day cycle, appreciating the structure it provides while still allowing for regular breaks.

References

DoubleBlind, “Microdosing Mushrooms w/ Paul Stamets”

https://www.youtube.com/watch?v=2ncriJF1hzQ

James Fadiman, “Might Microdosing Psychedelics Be Safe and Beneficial? An Initial Exploration”

https://pubmed.ncbi.nlm.nih.gov/30925850/

Carod-Artal, F.J. "Hallucinogenic drugs in pre-Columbian Mesoamerican cultures".

Disclaimer:

The information provided in this blog post is for educational and informational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or the use of psychedelic substances.

The use of psychedelic substances, including microdosing, carries inherent risks and may not be suitable for everyone. It is essential to conduct thorough research, carefully consider individual circumstances, and consult with a healthcare professional before embarking on any psychedelic journey or altering existing treatment regimens.

The authors of this blog post do not endorse or promote the illegal use of psychedelic substances. Any discussions regarding dosing protocols or personal experiences are provided for educational purposes only and should not be interpreted as encouragement to engage in illegal activities.

By reading this blog post, you acknowledge and accept that the authors and publishers are not liable for any consequences arising from the use of the information provided herein. Always prioritize safety, legality, and personal well-being when considering the use of psychedelic substances.